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Background: Sexual dimorphism in cardiac sympathetic outflow has recently gained attention in the context of Takotsubo cardiomyopathy. Previous studies suggest that there are sex- and age-dependent differences in peripheral autonomic control, however, data on cardiac-specific sympathetic activation in aged women and men are lacking. Methods and results: Regional quantitative analysis of cardiac fluorine 18F - Dihydroxyphenylalanine DOPA uptake was retrospectively performed in patients 69 females, mean age This sex-difference was most pronounced in the apical region of the left ventricle LV, 1. No age-dependent changes of cardiac 18F-DOPA uptake were observed in men or in the right ventricular region. Conclusion: Our study suggests that aging is related to sex-specific changes in regional cardiac sympathetic activity.
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